Watch RESOLVE’s National Infertility Awareness video here! Infertility is a disease or condition of the reproductive system. It is defined as not being able to get pregnant despite having frequent, unprotected sex for at least a year if you are under the age of 35, and for at least six months if the woman is age 35 or older. According to the Mayo Clinic, it affects an estimated 10 to 15% of couples in the United States who are trying to conceive. Infertility occurs in both women and men, and it is not something to be embarrassed about or ashamed of. There are many advances in this area of medicine that help infertile couples conceive, whether it be through hormone therapy, IVF, and/or assisted reproductive technologies such as surrogacy, egg donation, sperm donation, and embryo donation.